Nakshatra was born as the youngest daughter to late Kannada film director D. Rajendra Babu and former actress Sumithra. She has one elder sister, Umashankari, who is also an actress. Nakshatra has said that she had always wanted to become an actress.
Her parents were initially against her wish as she was their "pampered daughter" and did not want to see her go through any hardships. She is very pretty actress in kannda movies. The Malayalam film For Sale, in which she had a minor role, was her first release in 2013. She had her other release that year in Tamil, Arya Surya, Rama Narayanan's 126th directorial.
She was then signed for an "important role" in the Kannada film Fair & Lovely. A review from The Hindu, however, wrote that she had "nothing much to offer".In 2015, she first appeared in the Malayalam film Village Guys, in which she shared screen space with her mother again. Amongst her upcoming films is Kuchiku Kuchiku, in which she was directed by her father, who had completed the film before his death.
In Oru New Generation Pani directed by debutant Sankar Narayan, she would be seen as Indraja, a bold and well educated girl, who is brought up by her mother. At age 17, Nakshatra was spotted by director Sunil Kumar Desai at a function, who called her mother, Sumithra, and expressed interest in casting her in his film.
She was given the starring role in Desai's Saregama and shortly after landed a role in Gokula, which also became her maiden release, and one of the lead roles in Hare Rama Hare Krishna. She played a shy girl in Gokula and got to co-act with her mother. Critics were positive on her performance in that film, stating that she was "quite impressive", "steals the show" and "strikes in a small role".
Saregama went through several delays and was shelved later, while, due to conflicting schedules, she had to opt out of Hare Rama Hare Krishna, with the role going to Pooja Gandhi eventually. 2011 she had her first Tamil releases, Doo and Marudhavelu.